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Laboratory of Food Safety Control, Department of Science and Technology on Food Safety, Faculty of Biology-Oriented Science and Technology, Kindai University

業績

原著論文

21. A. Kato, S. Ueda, T. Oshima, Y. Inukai, T. Okajima, M. Igarashi, Y. Eguchi and R. Utsumi. Characterization of H-box region mutants of WalK inert to the action of waldiomycin in Bacillus subtilis. J. Gen. Appl. Microbiol., 63, 212-221, 2017.

20. Y. Eguchi, T. Okajima, N. Tochio, Y. Inukai, R. Shimizu, S. Ueda, S. Shinya, T. Kigawa, T. Fukamizo, M. Igarashi and R. Utsumi. Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases, J. Antibiotics. (Tokyo), 70, 251-258, 2017.
(Y. Eguchi, T. Okajima, N. Tochio contributed equally)

19. S. Miwa, E. Kihira, A. Yoshioka, K. Nakasone, S. Okamoto, M. Hatano, M. Igarashi, Y. Eguchi, A. Kato, N. Ichikawa, M. Sekine, N. Fujita, Y. Kanesaki, H. Yoshikawa and R. Utsumi. Identification of the three genes involved in controlling production of a phytotoxin tropolone in Burkholderia plantarii, J. Bacteriol., 198, 1604-1609, 2016.

18. E. Kinoshita-Kikuta, E. Kinoshita, Y. Eguchi, and T. Koike. Validation of Cis and Trans Modes in Multistep Phosphotransfer Signaling of Bacterial Tripartite Sensor Kinases by Using Phos-tag SDS-PAGE. PLoS One, e0148294.doi: 10.1371, 2016.

17. E. Kinoshita-Kikuta, E. Kinoshita, Y. Eguchi, S. Yanagihara, K. Edahiro, Y. Inoue, M. Taniguchi, M. Yoshida, K. Yamamoto, H. Takahashi, T. Sawasaki, R. Utsumi and T. Koike. Functional characterization of the receiver domain for phosphorelay control in hybrid sensor kinases. PLoS One, e0132598. doi: 10.1371, 2015.

16. M. Fakhruzzaman, Y. Inukai, Y. Yanagida, H. Kino, M. Igarashi, Y. Eguchi and R. Utsumi. Study on in vivo effects of bacterial histidine kinase inhibitor, Waldiomycin in Bacillus subtilis and Staphylococcus aureus. J. Gen. Appl. Microbiol., 61, 177-184, 2015.
(Y. Eguchi and R. Utsumi are corresponding authors)

15. Y. Eguchi and R. Utsumi. Alkali metals in addition to acidic pH activate the EvgS histidine kinase sensor in Escherichia coli, J. Bacteriol., 196, 3140-3149, 2014.

14. E. Ishii, Y. Eguchi, R. Utsumi. Activation mechanism of the PhoQ/PhoP two-component signal transduction by SafA, an auxiliary protein of the PhoQ histidine kinase in Escherichia coli, Biosci. Biotechnol. Biochem., 77, 814-819, 2013  (E. Ishii and Y. Eguchi contributed equally).

13. T. Watanabe, M. Igarashi, T. Okajima, E. Ishii, H. Kino, M. Hatano, R. Sawa, M. Umekita, T. Kimura, S. Okamoto, Y. Eguchi, Y. Akamatsu, and R. Utsumi. Isolation and Characterization of Signermycin B, an Antibiotic That Targets the Dimerization Domain of Histidine Kinase WalK. Antimicrob. Agents Chemother., 56, 3657-3663, 2012.

12. Y. Eguchi, E. Ishii, M. Yamane and R. Utsumi. The connector SafA interacts with the multi-sensing domain of PhoQ in Escherichia coli. Mol. Microbiol., 85, 299-313 (2012).

11. Y. Eguchi, E. Ishii, K. Hata, and R. Utsumi. Regulation of Acid Resistance by Connectors of Two-component Signal Transduction Systems in Escherichia coli. J. Bacteriol. 193, 1222-1228 (2011).

10. Y. Eguchi, N. Kubo, H. Matsunaga, M. Igarashi, and R. Utsumi. Development of an Antivirulence Drug against Streptococcus mutans: Repression of Biofilm Formation, Acid Tolerance, and Competence by a Histidine Kinase Inhibitor, Walkmycin C. Antimicrob. Agents Chemother., 55, 1475 - 1484 (2011) .

9. J. Itou, Y. Eguchi and R. Utsumi Molecular mechanism of transcriptional cascade initiated by the EvgS/EvgA system in Escherichia coli K-12. Biosci. Biotechnol. Biochem., 73, 870-878 (2009)  (J. Itou and Y. Eguchi contributed equally)

8. K. Hirata, C. Ishida, Y. Eguchi, K. Sakai, F. Ozoe, Y. Ozoe, K. Matsuda. Role of a serine residue (S278) in the pore-facing region of the housefly L-glutamate-gated chloride channel in determining sensitivity to noncompetitive antagonists. Insect Mol. Biol., 17, 341-350 (2008)

7. Y. Eguchi, J. Itou, M. Yamane, R. Demizu, F. Yamato, A. Okada, H. Mori, A. Kato and R. Utsumi B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli. Proc Natl Acad Sci USA, 104, 18712 - 18717 (2007)

6. E. Fujiwara-Nagata, Y. Eguchi, R. Utsumi, and M. Eguchi. Transcriptional regulation of the Na+-NADH:quinone oxidoreductase gene, nqr, in Vibrio anguillarum, a fish pathogen, in the stationary phase. Fisheries Science, 73, 348-355 (2007).

5. Y. Eguchi, M. Ihara, E. Ochi, Y. Shibata, K. Matsuda, S. Fushiki, H. Sugama, Y. Hamasaki, H. Niwa, M. Wada, F. Ozoe and Y. Ozoe. Functional characterization of Musca glutamate- and GABA-gated chloride channels expressed independently and coexpressed in Xenopus oocytes, Insect Mol. Biol., 15, 773-783 (2006)

4. Y. Eguchi, T. Okada, S. Minagawa, T. Ohshima, H. Mori, K. Yamamoto, A. Ishihama and R. Utsumi. Signal transduction cascade between EvgA/EvgS and PhoP/PhoQ two-component system in Escherichia coli, J. Bacteriol., 186, 3006-3014 (2004)

3. Y. Eguchi, T. Ohshima, H. Mori, R. Aono, K. Yamamoto, A. Ishihama and R. Utsumi. Transcriptional regulation of drug efflux genes by EvgAS, a two-component system in Escherichia coli, Microbiology, 149, 2819-2828 (2003)

2. S. Minagawa, H. Ogasawara, A. Kato, K. Yamamoto, Y. Eguchi, T. Ohshima, H. Mori, A. Ishihama and R. Utsumi. Identificition and molecular characterization of the Mg2+ stimulon of Escherichia coli. J. Bacteriol., 185, 3696-3702 (2003)

1. T. Kohzuki, Y. Eguchi, M.Kato, K. Irie, H. Ohtsuka, A. Higuchi and H. Noguchi. Protective activity of anti-exotoxinA monoclonal antibody against mice infected with toxin-producing Pseudomonas aeruginosa. J. Infect. Dis., 167, 119-125 (1993)


総説

5. 江口陽子、加藤明宣、石井英治、内海龍太郎 コネクターがつなぐ細菌情報伝達ネットワーク 化学と生物, 51, 241-249 (2013)

4. 江口陽子、内海龍太郎 細菌情報伝達阻害剤(TCS阻害剤)開発の現状 化学療法の領域, 29, 100-105 (2013).

3. Y. Gotoh, Y. Eguchi, T. Watanabe, S. Okamoto, A. Doi and R. Utsumi Two-component signal transduction as potential drug targets in pathogenic bacteria Curr. Opin. Microbiol., 13, 232-239 (2010) (Y. Gotoh and Y. Eguchi contributed equally)

2. 江口陽子、内海龍太郎 細菌情報伝達ネットワークとその阻害剤の開発 日本乳酸菌学会誌., 21, 36-41(2010)

1. Y. Eguchi and R. Utsumi. A novel mechanism for connecting bacterial two-component signal-transduction systems, Trends Biochem. Sci., 30, 70-72 (2005)


著書

4. Eguchi Y, Utsumi R., Chapter 16.3. Two-component systems in sensing and adaptation to acid stress in Escherichia coli, Stress and Environmental Control of Gene Expression in Bacteria, F. J. de Bruijn (Ed.), pp 927-934, 2016, Wiley-Blackwell Publishers.

3. Y. Eguchi, E. Ishii, and R. Utsumi. Molecular mechanism of bacterial two-component signal transduction networks via connectors, Two component systems in bacteria, R. Gross and D. Beier (Ed.), pp 149-162, 2012, Horizon Scientific Press.

2. Y. Eguchi and R. Utsumi. Introduction to bacterial signal transduction networks, Adv. Exp. Med. Biol.,631, 1-6(2008)

1. Y. Eguchi, S. Minagawa, H. Ogasawara, K. Yamamoto and R. Utsumi. Signal transduction network for environmental adaptation in Escherichia coli, Survival and Death in Bacteria, M. Yamada (Ed.), pp 69-76, 2005, Research Signpost (Kerara, India)


受賞

3. 優秀発表賞 受賞 「クラスI ヒスチジンキナーゼのH-boxを標的とする新規抗生物質、waldiomycin」2015/5/16 生化学会第62回近畿支部例会 ○清水 莉子、江口 陽子、犬飼 洋一、栃尾 尚哉、岡島 俊英、新家 粧子、深溝 慶、五十嵐 雅之、木川 隆則、内海 龍太郎

2. トピックス賞 受賞 「う蝕菌バイオフィルム形成に対するアロマデンドレン類縁化合物の阻害機構」 2011/3/28 日本農芸化学会 2011 年度大会  ○松永 弘子、江口 陽子、平瀬 創太、田中 康雄、内海 龍太郎

1. トピックス賞 受賞 「う蝕菌 Streptococcus mutans に対するヒスチジンキナーゼ阻害剤の病原性抑制効果」 2010/3/1 日本農芸化学会2010年度大会 ○江口 陽子、松永 弘子,小島 徳子,五十嵐 雅之,内海 龍太郎







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